Effect of the ketoprofen on the preemptive analgesia in female cats undergoing to ovariohysterectomy

Dayvid Vianêis Farias de Lucena, Fernanda Vieira Henrique, Amara Gyane Alves de Lima, Almir Pereira de Souza, Pedro Isidro da Nóbrega Neto

Resumo


The objective of this study was to investigate the effect of the ketoprofen on the preemptive analgesia in female cats
submitted to ovariohysterectomy. Sixteen healthy cats were distributed into two groups, with eight animals each, by
means of a draw, in a preemptive group (PREG), in which the animal received ketoprofen (1 mg/kg) subcutaneously two
hours before the surgery; and postsurgery group (POSG), in which ketoprofen (1 mg/kg) was administered subcutaneously
immediately after surgery. In both groups, ketoprofen was given 24, 48 and 72 hours after the first adminstration. Heart
and respiratory frequencies and glycemia were measured in all animals during the days first ten postsurgery. Analgesia
was measured by assigning scores at zero, two, four, six, 12, 24, 48, 72, 96, 120, 144, 168, 192, 216 and 240 hours after the surgical procedure. Statistical analysis was performed using two-way analysis of variance followed by Tukey’s test to
compare the moments and Student’s t-test for comparison between groups. Pain scores were evaluated using test of UMann-Withney or Kruskall-Wallis, all at the 5% level of significance. Pain scores were significantly lower in PREG in M0,
M6, M72, M96 and M120. No significant difference was found in the levels of glycemia in comparison to baseline values.
Ketoprofen promotes postsurgery analgesia in female cats submitted to ovariohysterectomy and preemptive and
postsurgery administration provides an earlier reduction of pain scores when compared to postoperative administration,
only.


Palavras-chave


antiinflamatório não esteroidal, dor, felino.

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Referências


Brondani JT, Luna SPL & Padovani CR (2011) Refinement and initial validation of a multidimensional composite scale for use in assessing acute postoperative pain in cats. American Journal Veterinary Research, 72: 174-183.

Burton AW, Lee DH, Saab C & Chung JM (1999) Preemptive intrathecal ketamine injection produces a long-lasting decrease in neuropathic pain behaviors in a rat model. Regional Anesthesia Pain Medicine, 24: 208-13.

Dobbins S, Brown NO & Shofer FS (2002) Comparison of the effects of buprenorphine, oxymorphone hydrochloride, and ketoprofen for postoperative analgesia after onychectomy or onychectomy and sterilization in cats. Journal of the American Animal Hospital Association, 38: 507-14.

Faria VP (2009) Avaliação Clínica, Laboratorial e Ecocardiográfica de Gatos Domésticos Hipertireóideos no período entre 2007 e 2008. Dissertação de Mestrado. Universidade Federal Rural do Rio de Janeiro, Seropédica.110p.

Fossum TW (2013) Small Animal Surgery. 4º ed. St. Louis, Elsevier. 1775p.

Fox SM & Johnston SA (1997) Use of carprofen for the treatment of pain and inflammation in dogs. Journal of the American Veterinary Medical Association, 210: 1493–1498.

Gauthier O, Holopherne-Doran D, Gendarme T, Chebroux A, Thorin C, Tainturier D & Bencharif D (2014) Assessment of Postoperative Pain in Cats After Ovariectomy by Laparoscopy, Median Celiotomy, or Flank Laparotomy. Veterinary Surgery, 9999: 1–8.

Gonçalves RC (2004) Semiologia do sistema respiratório. In: Feitosa FLF (Ed.) Semiologia Veterinária: arte do diagnóstico. São Paulo, Roca. p. 313-331.

Kamata M, King JN, Seewald W, Sakakibara N, Yamashita K & Nishimura R (2012) Comparison of injectable robenacoxib versus meloxicam for peri-operative use in cats: Results of a randomised clinical trial. The Veterinary Journal, 193: 114–118.

Slingsby LS & Waterman-Pearson AE (1998) Comparison of pethidine, buprenorphine and ketoprofen for postoperative analgesia after ovariohysterectomy in the cat. Veterinary Record, 143: 185–189.

Slingsby LS& Waterman-Pearson AE (2000) Postoperative analgesia in the cat after

ovariohysterectomy by use of carprofen, ketoprofen, meloxicam or tolfenamic acid. Journal of Small Animal Practice, 41: 447–450

Staffieri F, Centonze P, Gigante G, De Pietro L & Crovace A (2013) Comparison of the analgesic effects of robenacoxib, buprenorphine and their combination in cats after ovariohysterectomy. The Veterinary Journal, 197: 363–367.

Taylor PM & Robertson SA (2004) Pain management in cats – Past, present and future. Part 1. The cat is unique. Journal of Feline Medicine and Surgery, 6: 313–320.

Teixeira LR, Luna SPL, Taffarel MO, Lima AFM, Sousa NR, Joaquim JGF & Freitas PM (2013) Comparison of intrarectal ozone, ozone administered in acupoints and meloxicam for postoperative analgesia in bitches undergoing ovariohysterectomy. The Veterinary Journal, 197: 794-9.

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