Effect of the ketoprofen on the preemptive analgesia in female cats undergoing to ovariohysterectomy

Dayvid Vianêis Farias de Lucena, Fernanda Vieira Henrique, Amara Gyane Alves de Lima, Almir Pereira de Souza, Pedro Isidro da Nóbrega Neto


The objective of this study was to investigate the effect of the ketoprofen on the preemptive analgesia in female cats
submitted to ovariohysterectomy. Sixteen healthy cats were distributed into two groups, with eight animals each, by
means of a draw, in a preemptive group (PREG), in which the animal received ketoprofen (1 mg/kg) subcutaneously two
hours before the surgery; and postsurgery group (POSG), in which ketoprofen (1 mg/kg) was administered subcutaneously
immediately after surgery. In both groups, ketoprofen was given 24, 48 and 72 hours after the first adminstration. Heart
and respiratory frequencies and glycemia were measured in all animals during the days first ten postsurgery. Analgesia
was measured by assigning scores at zero, two, four, six, 12, 24, 48, 72, 96, 120, 144, 168, 192, 216 and 240 hours after the surgical procedure. Statistical analysis was performed using two-way analysis of variance followed by Tukey’s test to
compare the moments and Student’s t-test for comparison between groups. Pain scores were evaluated using test of UMann-Withney or Kruskall-Wallis, all at the 5% level of significance. Pain scores were significantly lower in PREG in M0,
M6, M72, M96 and M120. No significant difference was found in the levels of glycemia in comparison to baseline values.
Ketoprofen promotes postsurgery analgesia in female cats submitted to ovariohysterectomy and preemptive and
postsurgery administration provides an earlier reduction of pain scores when compared to postoperative administration,


antiinflamatório não esteroidal, dor, felino.

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